Butting in with an answer (though I'm sure Ishte won't mind): After reading Winry's part in the manga and comparing it to her part in the anime, I feel she became very much a "one note" character. She didn't have the range of expression she's received in the manga - in the anime, it seems like she's on one extreme of miserable and then the other extreme of happy - and more often than not, miserable. She doesn't feel as well-rounded and her sense of justice (and humor) seem misplaced in the anime.